Queen bee milk is also called queen bee stew, and its name is the food eaten by queen bee (Queen bee). Queen bee milk has been considered a nourishing product for a long time, especially in nursing and beauty and preventive health care. Many people...
Queen bee milk is also called queen bee stew, and its name is the food eaten by queen bee (Queen bee). Queen bee milk has been considered a nourishing product for a long time, especially in nursing and beauty and preventive health care. Many people think it has special effects. Among the questions that many beautiful good friends sponsors asked us to answer, queen bee milk is also a product that many people asked!
To help everyone understand what queen bee milk is? What are the nutrients? And what might be effective? After reviewing dozens of related articles, the team nutritionists and doctors compiled a complete guide to the queen bee milk, and analyzed the possible physiological effects from ingredients to related research. After reading this article, I believe you will definitely feel that you have re-understood queen bee milk.
? What is the difference between it and workbee milk?Royal Jelly is not only called queen bee flask, but sometimes it is also called queen bee flask. Queen bee milk, honey and bee gel are the main products of the breeding bee industry. Here are the simplest introductions to these three products:
●Honey: The nectar obtained by working bees from flowers is used as food for bees by repellent, enzyme action and water removal.●Bee: A mixture collected from the resins of several plants has the effects of antibacterial, anticorrosion and strengthening the honeycomb structure.
●Queen bee milk: food exclusive to the queen bee.
Queen bee milk is a nutrient produced by worker bees that are responsible for the breeding. It is a white milk liquid secreted by the hypopharyngeal gland and the Mandibular gland of the young worker bees. Queen bee milk can be partially dissolved in water at a pH of between 3.4-4.5. If you break down the ingredients of queen bee milk, it has a moisture content of 60-70%, protein quality of 9-18%, sugar quality of 10-15%, and contains a small amount of fat, vitamins, minerals and lying amino acids. The sugars in queen bee milk are mainly fructose and glucose, accounting for about 90% of all sugars and also contain sucrose, but the content changes greatly. In addition to the above-mentioned sugars, some oligosaccharides are also contained.
Just looking at this kind of nutritional ingredients description, you may think that queen bee milk is just a bit nutritious food. How can it be used as a nourishing thing? Here we need to understand the difference between the queen bee milk that is specially given to the queen bee and the workbee milk that is eaten by the young bee. The things that the king eats are different. Queen bee milk vs. Worker bee milk
In the same group of bees, the DNA of the queen bee and the worker bee is actually exactly the same, that is, when this large group of young bees were born, they were almost the same. But in the end, who will become a queen bee, or who will become a worker bee, actually, because the food eaten during the germination period is different, they will eventually have completely different fates. The saplings produced in the Queen's Terrace are the bees that grow up to become queens. Before growing into queens, they only eat queens milk to survive; while those saplings that grow up to become worker bees are the worker jelly.
If the nutritional status is good, the individual development will be better. Everyone should understand this principle. But the difference between queen bees and worker bees is not only that queen bees are larger, but also undergoes great changes in their physiology and behavior. For example, queen bees are fertile, but other worker bees do not. Why is this? The following paragraph is written for good-student children. If you only want to know the efficacy of queen bee milk, you can jump directly to the next paragraph.
To explain how the Queen Bee and Worker Bee are decided behind the mechanism, you have to come up with epigenetics. What is expressive education? To put it simply, it means that without changing biological DNA, through certain mechanisms, causing changes in gene expression, and the final result is that the characteristics of the organism change. These mechanisms include factors such as nutritional status or environmental conditions.
How did the queen bee swelling develop into queen bees? From the picture below, we can roughly know what events occurred in this: the food of the young cicada is identified by the epithelial cells of the tract and is given by fat (organs responsible for the storage of nutrients and reproduction in the cicada). The signal is then sent to the brain through intraocular signals, prompting the pharyngeal gland (corpora allata) to secrete juvenile hormone (juvenile hormone). It is necessary to have a high concentration of JH in the queen's cervix, while the worker's cervix is lower. On the contrary, the degree of DNA methylation of the worker's cervix is higher (the manifestation of the control gene), and the final result is the difference between the queen and the worker's cervix (Ref. 1).
On the general market, we won't see products with the nickname of the worker bee, but you may be curious about the difference between the nutrients of the worker bee and the queen bee milk. There is a study comparing the components of queen bee milk and worker bee milk of more Western bees. It was found that most of the nutrient content of queen bee milk is higher than that of worker bee milk. Detailed ingredient data are listed in the table below (Ref. 2). In addition, the data in the table will find that as the number of days increases, the ingredients of the two types of milk will also change. Why is this? As the age of working bees grows, the ingredients of queen bee milk or workbee milk produced every day will also change..
Because queen bee milk on different days has different ingredients, you may see that some products are specially labeled as the queen bee milk on which day they are collected and emphasize that the active ingredients are more content.
But everyone will definitely think that there should be only one queen bee in a bee, and the production of queen bee milk must be very small. How to get a whole can that can be sold? The bee farming will put dozens of artificial queen bees in a beehive, making the worker bees think that the young bees in these queen bees are future queen bees, so they will secrete queen bees and enter. Next, bee farmers will collect on the third day, but this process is usually more difficult and the yield is naturally not as much as honey. The nutrient composition of the queen bee milk that may have efficacy contains some vitamins and minerals in the queen bee milk in addition to the ingredients listed on the table. Among these ingredients, there are two main physiologically active ingredients. One is a non-hydroxy-trans-2-decenoic acid (simplely 10-HDA); the other is a slightly complex major royal Jelly Proteins (simplely MRJPs). The following discussion is more complicated. If you only want to know what effects may be, you can directly read the next paragraph.
There are currently 9 MRJPs known (below), among which more MRJP1 studies are studied, which is also the key protein that generally believes that honeybee germs develop into queen bees. However, other MRJPs may also participate in the development process. After analysis, it was found that sperminic acid, platinum acid, lemonic acid, lemonic acid, methiamine, amphetyl acid, somelamine, tryptic acid and amylin acid are the ten most common amino acids in MRJPs. They and other amino acids synthesize MRJPs with different structures and molecular weights in various ways. For example, MRJP1, 2 and 4 have many leukoacids and amylic acids, while the main amino acids of MRJP3 are sperminic acids and ionic acids.
In addition, various MRJPs have different forms. For example, MRJP1 may also exist in a single, oligomer or water-soluble form, and may have different physiological effects (for bees). royalactin is a single type of MRJP1, which can induce physiological changes in the larvae, causing the body and ovary size to increase and shorten the growth and development time, allowing the larvae to develop into a queen bee (Ref. 3).
The physiological effects of various MRJPs in the picture below are mostly discoveries of cell tests and animal tests. It is still uncertain whether the same effects can be found in humans in fact. In addition, worker bees have to start working when they grow to a certain level. On the sixth day, they start working in the interior and are responsible for growing the saplings in the beehive. On the twelfth day, they will start running the field and go to the four places to pick up honey.
What are the effects of queen bee milk? It should be noted that many ingredients that are effective in cell or animal tests may not necessarily work in humans. Therefore, in the previous paragraph, although we saw that queen bee milk has many effects, we still have to verify it from clinical trials to be accurate. Below we will list some clinical trials related to queen bee milk. If you are not interested, you can directly look at the key points of the rough words.
Queen bee milk may help with wound complications
In 2011, a small clinical trial targeting 8 diabetes patients, assessing what effect queen bee milk has on wound complications in diabetic foot complications. There are two treatment methods for research. Common treatments and the use of ointment containing 5% aseptic queen bee milk on the wound (it is external, not for use). It was found that in the treatment of foot aches in patients with diabetes, the effect of Queen Bee Latex is better (Ref. 4).Queen bee milk may reduce risk of cardiovascular disease
There are studies that have been found for healthy adults, but mild hypersitolemia, to be given randomly to queen bee milk and comfort kits. During the three-month study period, Queen bee milk was taken 9 capsules containing 350 mg of queen bee milk per day. As a result, it was found that the total cervical sterol and LDL decreased significantly and the concentration of DHEA-S in the blood was significantly improved. Therefore, taking queen bee milk may help improve DHEA-S and thus reduce the risk of cardiovascular disease (Ref. 5). But pay attention to this intake, which is actually quite a lot~In addition, DHEA-S is a slimming of Dehydroepianandrosterone sulfate. Low blood concentration may be related to obesity, cardiovascular disease, and autoimmune diseases; excessive highs may be related to feminine hirsutism and feminine sulphate.
Queen bee milk may help with blood sugar control and antioxidant in diabetes
There is a clinical trial targeting 50 women with type 2 diabetes (Ref. 6). Research studies randomly arrange for them to go to a queen bee milk or a soothing agent. The queen bee milk is filled with a soft capsule containing 1 gram of queen bee milk every day. The soothing agent is a daily capsule without queen bee milk. The test is conducted for 8 weeks. Before and after the study began, the blood sugar, antioxidants and oxidative pressure of the subjects were measured.The results found that supplementation of queen bee milk seems to help blood sugar control and reduce oxidative pressure in diabetic patients, but it requires larger studies to be determined.
In addition, there were also studies that found 20 healthy people to eat queen bee milk and observe the effects on blood sugar. The study allowed the subjects to undergo two oral glucose tolerance tests, one was a standard test method, and then the subjects were asked to take 20 grams of queen bee milk first and then the test was conducted. It turned out that after taking queen bee milk, the blood sugar and glucose curves after two hours were significantly lower (Ref. 7).
However, in 2015, there was a study on queen bee milk supplementation that also gave patients with type 2 sugar. The experiment method was different from the above study. This study found 40 patients who were randomly assigned to a fresh queen bee milk or a comfort set of 10 grams a day. The subjects would eat queen bee milk or a comfort set on an empty stomach early in the morning, and measure the concentration of blood sugar, insulin and C-peptide after consumption 0, 60 and 120 minutes.
result found that there is no significant difference in the various values between the two groups. Therefore, researchers believe that a larger scale and different queen bee milk dosages are needed to more accurately evaluate its blood sugar effect on patients with type 2 diabetes (Ref. 8).
Queen bee milk may relieve menopause symptoms
There is a random soothing agent-control group study in Japan targeting healthy menopause women. The subjects were supplemented with 800 mg of queen bee milk or soothing agent every day for 12 weeks. It was found that queen bee milk may relieve the menopause symptoms in the subject, such as anxiety, head pain and lower back pain (Ref. 9).Queen bee milk may resolve pre-synchronization
In 2014, there was a study in Iran with 110 female college students with pre-synchronization (PMS). The experiment design is a three-blind, random, and consolation control method. The study randomly assigned female college students to queen bee vaginal capsules (1 g/day) or consolation kits for two consecutive months, and the symptoms were evaluated using the questionnaire for pre- and post-test. The results found that the PMS rating of queen bee milk was significantly lower than that of the pussy agent group, and this study proved that supplementation of queen bee milk might help reduce the symptoms of PMS, but a larger scale of research will be required to verify the results of this study (Ref. 10).Queen bee milk may improve dry eye disease
In Japan, there was a prospective study of 43 patients with dry eye disease. The subjects were randomly assigned to queen bee milk or comfort agents. The study was conducted for 8 weeks, and during which the queen bee milk had to take 6 tablets containing 1.2 grams of queen bee milk every day. The researchers evaluated the subjects' horn membrane epithelial injury, tear film break-up time, clean fluid secretion, lipid volume, blood biochemical data, and asked the subjects to fill in questions about dry eye disease at the beginning of the study, the fourth and eighth weeks. It was found that queen bee milk may increase the secretion of the liquid (Ref. 11).Finally, I need to emphasize one thing. Although the above research is clinical trial, it is not enough in terms of scale and quality to allow us to get a positive conclusion. Don’t think that if you eat queen bee milk, you will definitely get the same effect.
How to preserve queen bee milk? What should I pay attention to?In the clinical study we have seen, the subjects did not have any side effects when eating queen bee milk, but please pay attention to the following four points:
Fresh queen bee milk is better than ice
If you want to buy new queen bee milk products, the recycling process and whether to "refrigerate" afterwards are the key points to consider. The reason is that the protein decomposition enzymes of queen bee milk are still exerting effects, and continue to decompose the protein of queen bee milk, 4° C The following environments can avoid this process, but some studies suggest that ice-cold ingredients can be further prevented from being damaged (Ref. 12). What if it wasn't ice? Then please finish eating as soon as possible and store it in the refrigerator.The longer the queen bee milk is, the more yellow the color it is?
The queen bee milk produced by the breeder bee is a milky white liquid, but the color will gradually change yellow after being placed. This is because the sugar in the queen bee milk has a plum reaction and the protein. Putting it in the refrigerator can delay this reaction.Is there any difference between fresh and cold-dried queen bee milk?
The biggest difference between the two is the moisture content. The moisture content of fresh queen bee milk can be as high as 70%. It can remove most of the moisture (less than 5%) through cold drying techniques, and generally 10-HDA is used as the product specification. After removing moisture, the powder is small and suitable for making capsules or staplers. Some people may not dare to eat fresh queen bee milk directly, so cold-dried products made into capsules are alternative options.Question of Queen Bee Milk
Bee Farm can easily determine the authenticity of Queen Bee Milk, but for consumers who have never encountered it, it is difficult to know the quality of Queen Bee Milk in front of you. Taiwan has set national standards for queen bee hygiene. Some breeders who join the Taiwan Nutrition Association can apply for queen bee milk verification from the association, and they can verify and approve the certification sticker from the quality and experience standards, so that manufacturers can post it on the product.The quality standards of the nude bee milk of
General Status Standard
●Type: It should be a milk gel, with uniform quality, no particles, but it has a particle feeling and no liquid separation.
●Color: white to light yellow.
●Miscellaneous quality: There must be no crumbs, juvenile bodies, bubbles or miscellaneous substances.
●Aura: It has a distinctly harsh and spicy taste, with a slightly sweet aftertaste, and must not have any odors such as fermentation, smell, etc.
Ingredient content standard
Ordinary consumers can check on the official website of the Taiwan Nutrition Association that currently has applicants for certification in Taiwan. In addition, considering cost expenditure, smaller breeders may not necessarily give their own experience or entrust Taiwan breeding associations to verify.
Who is not suitable for eating queen bee milk
Queen bee milk may cause allergies
Although the MRJPs of queen bee milk are physiologically active, someone may have allergies to them, so eating queen bee milk may also cause allergies. If you experience allergic reactions after taking queen bee milk, you must include queen bee milk in the list of suspects. The clinical doctor will help you determine what causes allergies..Breast cancer or a family history of breast cancer
According to cell and animal trial studies, it was found that queen bee milk has the effect of activating estrogen receptors. Whether this will promote the proliferation of breast cancer cells (Ref. 14), there is no accurate answer to this. The reason is that it allows breast cancer mice (4T1-bearing mice) to supplement queen bee milk, and found that queen bee milk can reduce the development of tumor cells in mice and adjust the gene expression related to immunity in the body (Ref. 15). Since there are positive and negative research conclusions, and queen bee milk is not a product that must be eaten, we do not recommend breast cancer patients or people with higher estrogen risks, such as patients with germ fibroids, to supplement queen bee milk separately until there is no accurate answer.Children before adolescence do not recommend eating
from relevant literature searches, and it is not clear what impact the estrogenic effect of queen bee milk will have on prepubertal children, so it is not advisable to recommend these people to supplement queen bee milk.Seeing this, do you have more understanding of queen bee milk? Of course, I still need to remind you that if you want to buy fresh queen bee milk, remember to buy ones with ice. However, if it is made into capsules, skeletons, or a product with a standard cold and dryness, this is not allowed. This article was completed after reviewing a bunch of articles. If you think this article is helpful to you, please like us and share it with your friends..
Reference1.Maleszka, R. (2008). Epigenetic integration of environmental and genomic signals in honey bees: the critical interplay of nutritional, brain and reproductive networks. Epigenetics, 3(4), 188-192.
2.Wang, Y., Ma, L., Zhang, W., Cui, X., Wang, H., & Xu, B. (2016). Comparison of the nutrient composition of royal jelly and worker jelly of honey bees (Apis melllifera). Apidologie, 47(1), 48-56.
3.Ramanathan, A. N. K. G., Nair, A. J., & Sugunan, V. S. (2018). A review on Royal Jelly proteins and peptides. Journal of Functional Foods, 44, 255-264.
4.Siavash, M., Shokri, S., Haghighhi, S., Mohammadi, M., Shahtalebi, M. A., & Farajzadehgan, Z. (2011). The efficiency of topical Royal Jelly on diabetic foot ulcers healing: A case series. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 16(7), 904.
5. Chiu, H. F., Chen, B. K., Lu, Y. Y., Han, Y. C., Shen, Y. C., Venkatakrishnan, K., … & Wang, C. K. (2017). Hypocholesterolemic efficiency of royal jelly in healthy mild hypercholesterolemic adults. Pharmaceutical biology, 55(1), 497-502.
6.Pourmoradian, S., Mahdavi, R., Mobasseri, M., Faramarzi, E., & Mobasseri, M. (2014). Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a randomized clinical trial. Chinese journal of integrated medicine, 20(5), 347-352.
7.Münstedt, K., Bargello, M., & Hauenschild, A. (2009). Royal jelly reduces the serum glucose levels in healthy subjects. Journal of Medicinal food, 12(5), 1170-1172.
8.Mobasseri, M., Ghiyasvand, S., Ostadrahimi, A., Ghojazadeh, M., Noshad, H., & Pourmoradian, S. (2015). Effect of fresh royal jelly ingestion on glycemic response in patients with type 2 diabetes. Iranian Red Crescent Medical Journal, 17(9).
9. Asama, T., Matsuzaki, H., Fukushima, S., Tatefuji, T., Hashimoto, K., & Takeda, T. (2018). Royal Jelly Supplementation Improves Menopausal Symptoms Such as Backache, Low Back Pain, and Anxiety in Postmenopausal Japanese Women. Evidence-Based Complementary and Alternative Medicine, 2018.
10.Taavoni, S., Barkhordari, F., Goushegir, A., & Haghani, H. (2014). Effect of Royal Jelly on premenstrual syndrome among Iranian medical sciences students: A randomized, triple-blind, placebo-controlled study. Complementary therapies in medicine, 22(4), 601-606.
11.Inoue, S., Kawashima, M., Hisamura, R., Imada, T., Izuta, Y., Nakamura, S., … & Tsubota, K. (2017). Clinical evaluation of a royal jelly supplementation for the restoration of dry eye: A prospective randomized double blind placebo controlled study and an experimental mouse model. PloS one, 12(1), e0169069.
12.Li, J. K., Wang, T., & Peng, W. J. (2007). Comparative analysis of the effects of different storage conditions on major royal jelly proteins. Journal of Apicultural Research, 46(2), 73-80.
13. Taiwan Nutrition Association – Queen Bee Dairy Quality Verification and Inspection Standard (2018.7.30)
14.Mishima, S., Suzuki, K. M., Isohama, Y., Kuratsu, N., Araki, Y., Inoue, M., & Miyata, T. (2005). Royal jelly has estrogenic effects in vitro and in vivo. Journal of ethnopharmacology, 101(1-3), 215-220.
15.Zhang, S., Nie, H., Shao, Q., kalan Hassanyar, A., & Su, S. (2017). RNA-Seq analysis on effects of royal jelly on tumour growth in 4T1-bearing mice. Journal of Functional Foods, 36, 459-466.
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